[(NHC)2Cu]X Complexes as Efficient Catalysts for Azide-Alkyne Click Chemistry at Low Catalyst Loadings

被引：257

作者：

Diez-Gonzalez, Silvia ^{[1
]}

Nolan, Steven P. ^{[1
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 46期

关键词：

alkynes; azides; click chemistry; copper; N-heterocyclic carbenes;

D O I：

10.1002/anie.200803289

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) La click, c'est chic! A catalytic system based on an [(NHC)2Cu]X complex (NHC=N-heterocyclic carbene) was developed for the [3+2] cycloaddition of azides with alkynes under click conditions (see scheme). This system is broad in scope and highly efficient (turnover frequencies up to 5000 h-1) even at very low catalyst loadings (down to 40 ppm). Preliminary mechanistic studies suggest a specific precatalyst-activation pathway. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8881 / 8884

页数：4

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