PHRENIC NERVE STIMULATION PROTECTS AGAINST MECHANICAL VENTILATION-INDUCED DIAPHRAGM DYSFUNCTION IN RATS

被引：39

作者：

Yang, Meirong ^{[1
]}

Wang, Haitao ^{[1
]}

Han, Guangwei ^{[1
]}

Chen, Lianhua ^{[1
]}

Huang, Lina ^{[1
]}

Jiang, Jihong ^{[1
]}

Li, Shitong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Peoples Hosp 1, Dept Anesthesiol, Shanghai 200080, Peoples R China

来源：

MUSCLE & NERVE | 2013年 / 48卷 / 06期

基金：

中国国家自然科学基金;

关键词：

diaphragm; electric stimulation therapy; mechanical ventilation; muscle weakness; phrenic nerve; UBIQUITIN-PROTEASOME SYSTEM; SKELETAL-MUSCLE; ATROPHY; GROWTH; IGF-1;

D O I：

10.1002/mus.23850

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We investigated a novel application of phrenic nerve stimulation (PNS) in diaphragm dysfunction induced by mechanical ventilation (MV). Methods: Twenty-one Sprague-Dawley rats were assigned randomly to 3 groups: spontaneous breathing, 18-h controlled MV, and 18-h controlled MV with PNS. Upon completion of the experimental protocol, diaphragm contractility, gene expression of insulin-like growth factor-1 (IGF-1) and ubiquitin ligases, and serum IGF-1 levels were analyzed. Results: Compared with the spontaneously breathing rats, impaired diaphragm contractile function, including force-related properties and force-frequency responses, were pronounced with MV. Furthermore, MV suppressed IGF-1 and induced muscle ring finger 1 mRNA expression in the diaphragm. In contrast, PNS counteracted MV-induced gene expression changes in the diaphragm and restored diaphragm function. Conclusions: PNS exerted a protective effect against MV-induced diaphragm dysfunction by counteracting altered expression of IGF-1 and ubiquitin ligase in the diaphragm. Muscle Nerve48: 958-962, 2013

引用

页码：958 / 962

页数：5

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