Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery

被引：252

作者：

Park, Ji-Ho ^{[1
]}

von Maltzahn, Geoffrey ^{[2
]}

Ruoslahti, Erkki ^{[3
]}

Bhatia, Sangeeta N. ^{[2
]}

Sailor, Michael J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Univ Calif Santa Barbara, Burnham Inst Med Res, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 38期

基金：

美国国家卫生研究院;

关键词：

antitumor agents; drug delivery; magnetic nanoparticles; micelles; quantum dots;

D O I：

10.1002/anie.200801810

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Multimodal nanoassemblies that contain magnetic nanoparticles, quantum dots, and the anticancer drug doxorubicin within a single PEG-phospholipid micelle were prepared (see scheme; PEG = poly-(ethylene glycol)). When equipped with the targeting peptide F3, these nanostructures enable simultaneous targeted drug delivery and dual-mode imaging of tumor tissues by near-infrared fluorescence and NMR spectroscopy. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7284 / 7288

页数：5

共 46 条

[21]

Kim J., 2006, ANGEW CHEM, V118, P7918, DOI DOI 10.1002/ange.200602471

[22] Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy [J].

Kim, Jaeyun ;

Park, Sungjin ;

Lee, Ji Ean ;

Jin, Seung Min ;

Lee, Jung Hee ;

Lee, In Su ;

Yang, Ilseung ;

Kim, Jun-Sung ;

Kim, Seong Keun ;

Cho, Myung-Haing ;

Hyeon, Taeghwan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (46) :7754-7758

[23] Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma [J].

Lee, Jae-Hyun ;

Jun, Young-Wook ;

Yeon, Soo-In ;

Shin, Jeon-Soo ;

Cheon, Jinwoo .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (48) :8160-8162

[24]

Lee JH, 2006, Angew. Chem., V118, P8340, DOI DOI 10.1002/ANGE.200603052

[25] In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice [J].

Liu, Zhuang ;

Cai, Weibo ;

He, Lina ;

Nakayama, Nozomi ;

Chen, Kai ;

Sun, Xiaoming ;

Chen, Xiaoyuan ;

Dai, Hongjie .

NATURE NANOTECHNOLOGY, 2007, 2 (01) :47-52

[26] Polyethylene glycol-diacyllipid micelles demonstrate increased acculumation in subcutaneous tumors in mice [J].

Lukyanov, AN ;

Gao, ZG ;

Mazzola, L ;

Torchilin, VP .

PHARMACEUTICAL RESEARCH, 2002, 19 (10) :1424-1429

[27] Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review [J].

Maeda, H ;

Wu, J ;

Sawa, T ;

Matsumura, Y ;

Hori, K .

JOURNAL OF CONTROLLED RELEASE, 2000, 65 (1-2) :271-284

[28] Encapsulation of magnetic and fluorescent nanoparticles in emulsion droplets [J].

Mandal, SK ;

Lequeux, N ;

Rotenberg, B ;

Tramier, M ;

Fattaccioli, J ;

Bibette, J ;

Dubertret, B .

LANGMUIR, 2005, 21 (09) :4175-4179

[29] Quantum dot bioconjugates for imaging, labelling and sensing [J].

Medintz, IL ;

Uyeda, HT ;

Goldman, ER ;

Mattoussi, H .

NATURE MATERIALS, 2005, 4 (06) :435-446

[30] Quantum dots for live cells, in vivo imaging, and diagnostics [J].

Michalet, X ;

Pinaud, FF ;

Bentolila, LA ;

Tsay, JM ;

Doose, S ;

Li, JJ ;

Sundaresan, G ;

Wu, AM ;

Gambhir, SS ;

Weiss, S .

SCIENCE, 2005, 307 (5709) :538-544

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