Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery

被引：252

作者：

Park, Ji-Ho ^{[1
]}

von Maltzahn, Geoffrey ^{[2
]}

Ruoslahti, Erkki ^{[3
]}

Bhatia, Sangeeta N. ^{[2
]}

Sailor, Michael J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Univ Calif Santa Barbara, Burnham Inst Med Res, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 38期

基金：

美国国家卫生研究院;

关键词：

antitumor agents; drug delivery; magnetic nanoparticles; micelles; quantum dots;

D O I：

10.1002/anie.200801810

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Multimodal nanoassemblies that contain magnetic nanoparticles, quantum dots, and the anticancer drug doxorubicin within a single PEG-phospholipid micelle were prepared (see scheme; PEG = poly-(ethylene glycol)). When equipped with the targeting peptide F3, these nanostructures enable simultaneous targeted drug delivery and dual-mode imaging of tumor tissues by near-infrared fluorescence and NMR spectroscopy. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7284 / 7288

页数：5

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