Unravelling the mechanisms of durable control of HIV-1

被引：182

作者：

Walker, Bruce D. ^{[1
,2
]}

Yu, Xu G. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ragon Inst MGH & Harvard, Cambridge, MA 02139 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; HLA CLASS-I; NATURAL-KILLER-CELLS; LONG-TERM SURVIVOR; LOW-LEVEL VIREMIA; ELITE CONTROLLERS; NEUTRALIZING ANTIBODIES; DENDRITIC CELLS; VIRAL CONTROL;

D O I：

10.1038/nri3478

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of infected individuals remain healthy and have normal CD4(+) T cell counts and undetectable viral loads; some individuals have remained this way for 35 years and counting. Through a combination of large population studies of cohorts of these 'HIV-1 controllers' and detailed studies of individual patients, a heterogeneous picture has emerged regarding the basis for this remarkable resistance to AIDS progression. In this Review, we highlight the host genetic factors, the viral genetic factors and the immunological factors that are associated with the controller phenotype, we discuss emerging methodological approaches that could facilitate a better understanding of spontaneous HIV-1 immune control in the future, and we delineate implications for a 'functional cure' of HIV-1 infection.

引用

页码：487 / 498

页数：12

共 139 条

[31] Inadequate T follicular cell help impairs B cell immunity during HIV infection [J].

Cubas, Rafael A. ;

Mudd, Joseph C. ;

Savoye, Anne-Laure ;

Perreau, Matthieu ;

van Grevenynghe, Julien ;

Metcalf, Talibah ;

Connick, Elizabeth ;

Meditz, Amie ;

Freeman, Gordon J. ;

Abesada-Terk, Guillermo, Jr. ;

Jacobson, Jeffrey M. ;

Brooks, Ari D. ;

Crotty, Shane ;

Estes, Jacob D. ;

Pantaleo, Giuseppe ;

Lederman, Michael M. ;

Haddad, Elias K. .

NATURE MEDICINE, 2013, 19 (04) :494-+

[32] Coordinate linkage of HIV evolution reveals regions of immunological vulnerability [J].

Dahirel, Vincent ;

Shekhar, Karthik ;

Pereyra, Florencia ;

Miura, Toshiyuki ;

Artyomov, Mikita ;

Talsania, Shiv ;

Allen, Todd M. ;

Altfeld, Marcus ;

Carrington, Mary ;

Irvine, Darrell J. ;

Walker, Bruce D. ;

Chakraborty, Arup K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :11530-11535

[33] Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: Evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses [J].

Decks, Steven G. ;

Schweighardt, Becky ;

Wrin, Terri ;

Galovich, Justin ;

Hoh, Rebecca ;

Sinclair, Elizabeth ;

Hunt, Peter ;

McCune, Joseph M. ;

Martin, Jeffrey N. ;

Petropoulos, Christos J. ;

Hecht, Frederick M. .

JOURNAL OF VIROLOGY, 2006, 80 (12) :6155-6164

[34] Human immunodeficiency virus controllers: Mechanisms of durable virus control in the absence of antiretroviral therapy [J].

Deeks, Steven G. ;

Walker, Bruce D. .

IMMUNITY, 2007, 27 (03) :406-416

[35] Towards an HIV cure: a global scientific strategy [J].

Deeks, Steven G. .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (08) :607-614

[36] Breadth of Human Immunodeficiency Virus-Specific Neutralizing Activity in Sera: Clustering Analysis and Association with Clinical Variables [J].

Doria-Rose, Nicole A. ;

Klein, Rachel M. ;

Daniels, Marcus G. ;

O'Dell, Sijy ;

Nason, Martha ;

Lapedes, Alan ;

Bhattacharya, Tanmoy ;

Migueles, Stephen A. ;

Wyatt, Richard T. ;

Korber, Bette T. ;

Mascola, John R. ;

Connors, Mark .

JOURNAL OF VIROLOGY, 2010, 84 (03) :1631-1636

[37] Magnitude of functional CD8+ T-cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma [J].

Edwards, BH ;

Bansal, A ;

Sabbaj, S ;

Bakari, J ;

Mulligan, MJ ;

Goepfert, PA .

JOURNAL OF VIROLOGY, 2002, 76 (05) :2298-2305

[38] Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection [J].

Elahi, Shokrollah ;

Niki, Toshiro ;

Hirashima, Mitsuomi ;

Horton, Helen .

BLOOD, 2012, 119 (18) :4192-4204

[39] Protective HIV-specific CD8+ T cells evade Treg cell suppression [J].

Elahi, Shokrollah ;

Dinges, Warren L. ;

Lejarcegui, Nicholas ;

Laing, Kerry J. ;

Collier, Ann C. ;

Koelle, David M. ;

McElrath, M. Juliana ;

Horton, Helen .

NATURE MEDICINE, 2011, 17 (08) :989-U110

[40] HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control [J].

Emu, Brinda ;

Sinclair, Elizabeth ;

Hatano, Hiroyu ;

Ferre, April ;

Shacklett, Barbara ;

Martin, Jeffrey N. ;

McCune, J. M. ;

Decks, Steven G. .

JOURNAL OF VIROLOGY, 2008, 82 (11) :5398-5407

← 1 2 3 4 5 6 7 8 9 10 →