Chemosensitization effects of XIAP downregulation in K562 leukemia cells

被引：44

作者：

Lima, RT

Martins, LM

Guimaraes, JE

Sambade, C

Vasconcelos, MH

机构：

[1] Univ Porto, IPATIMUP, Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal

[2] MRC, Toxicol Unit, Leicester, Leics, England

[3] Univ Porto, Fac Med, P-4100 Oporto, Portugal

[4] Hosp Sao Joao, Oporto, Portugal

[5] Univ Porto, Fac Pharm, Dept Microbiol, P-4100 Oporto, Portugal

来源：

JOURNAL OF CHEMOTHERAPY | 2006年 / 18卷 / 01期

关键词：

antisense; xIAP; CML; apoptosis; chemosensitization;

D O I：

10.1179/joc.2006.18.1.98

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The effect of downregulation of the expression of the antiapoptotic protein XIAP with antisense oligonucleotides was evaluated in the K562 chronic myeloid leukemia (CML) cell line. This was carried out by studying the effects of downregulation of XIAP expression on cellular viability, cellular apoptosis and on the response to two chemotherapeutical drugs, etoposide and doxorubicin. We document that downregulation of XIAP expression decreased cellular viability, increased cellular apoptosis and enhanced the effects of doxorubicin.

引用

页码：98 / 102

页数：5

共 20 条

[1]

Amantana A, 2004, MOL CANCER THER, V3, P699

[2]

Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia [J].