miR-107-5p promotes tumor proliferation and invasion by targeting estrogen receptor-α in endometrial carcinoma

被引：37

作者：

Bao, Wei ^{[1
]}

Zhang, Yan ^{[1
]}

Li, Shuangdi ^{[1
]}

Fan, Qiong ^{[2
]}

Qiu, Meiting ^{[3
]}

Wang, Yanan ^{[1
]}

Li, Yanli ^{[1
]}

Ji, Xiaoning ^{[1
]}

Yang, Ye ^{[1
]}

Sang, Zhenyu ^{[1
]}

Xu, Wei ^{[1
]}

Yang, Yongbin ^{[1
]}

Wu, Sufang ^{[1
]}

Zhu, Yaping ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Shanghai Gen Hosp, Sch Med, 100 Haining Rd, Shanghai 200080, Peoples R China

[2] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Int Peace Matern & Child Hlth Hosp, Sch Med, Shanghai 200030, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Obstet & Gynecol, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China

来源：

ONCOLOGY REPORTS | 2019年 / 41卷 / 03期

基金：

中国国家自然科学基金;

关键词：

endometrial carcinoma; miR-107-5p; ER alpha; proliferation; invasion; prognosis; STEROID-RECEPTORS; EXPRESSION; MICRORNAS; AMPLIFICATION; PROGESTERONE; METASTASIS; HORMONES; CELLS;

D O I：

10.3892/or.2018.6936

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The aberrant expression of miR107-5p is closely related to the development of several types of human cancers. However, the role of miR-107-5p in endometrial carcinoma (EC) has not been fully confirmed. In the present study, we aimed to explore the function of miR-107-5p in EC carcinogenesis. EC samples and normal endometrial tissues were obtained by laser capture microdissection. It was determined that the expression of miR-107-5p in EC was significantly higher than that in normal endometrium, and higher miR-107-5p expression was related to advanced FIGO stages, lymph node metastasis and myometrial invasion in EC patients. Blocking miR-107-5p significantly inhibited cell proliferation, migration and invasion of EC cells in vitro and in vivo. The results of bioinformatic algorithms and luciferase reporter assays revealed that estrogen receptor (ER) was a direct target of miR-107-5p. miR-107-5p downregulated the expression of ER mRNA and protein. In conclusion, our results highlighted that miR-107-5p is a novel prognostic factor that targets ER to promote tumor proliferation and invasion of EC.

引用

页码：1575 / 1585

页数：11

共 39 条

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