The model organism as a system: integrating 'omics' data sets

被引：468

作者：

Joyce, AR

Palsson, BO

机构：

[1] Univ Calif San Diego, Bioinformat Program, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 03期

关键词：

D O I：

10.1038/nrm1857

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Various technologies can be used to produce genome-scale, or 'omics', data sets that provide systems-level measurements for virtually all types of cellular components in a model organism. These data yield unprecedented views of the cellular inner workings. However, this abundance of information also presents many hurdles, the main one being the extraction of discernable biological meaning from multiple omics data sets. Nevertheless, researchers are rising to the challenge by using omics data integration to address fundamental biological questions that would increase our understanding of systems as a whole.

引用

收藏

页码：198 / 210

页数：13

相关论文

共 129 条

[11] ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments [J].

Buck, MJ ;

Lieb, JD .

GENOMICS, 2004, 83 (03) :349-360

[12] Interaction network containing conserved and essential protein complexes in Escherichia coli [J].

Butland, G ;

Peregrín-Alvarez, JM ;

Li, J ;

Yang, WH ;

Yang, XC ;

Canadien, V ;

Starostine, A ;

Richards, D ;

Beattie, B ;

Krogan, N ;

Davey, M ;

Parkinson, J ;

Greenblatt, J ;

Emili, A .

NATURE, 2005, 433 (7025) :531-537

[13] Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs [J].

Cawley, S ;

Bekiranov, S ;

Ng, HH ;

Kapranov, P ;

Sekinger, EA ;

Kampa, D ;

Piccolboni, A ;

Sementchenko, V ;

Cheng, J ;

Williams, AJ ;

Wheeler, R ;

Wong, B ;

Drenkow, J ;

Yamanaka, M ;

Patel, S ;

Brubaker, S ;

Tammana, H ;

Helt, G ;

Struhl, K ;

Gingeras, TR .

CELL, 2004, 116 (04) :499-509

[14]

*CHIMP SEQ AN CONS, 2005, NATURE, V0437

[15] Nutrigenomics:: The impact of biomics technology on nutrition research [J].

Corthésy-Theulaz, I ;

den Dunnen, JT ;

Ferré, P ;

Geurts, JMW ;

Müller, M ;

van Belzen, N ;

van Ommen, B .

ANNALS OF NUTRITION AND METABOLISM, 2005, 49 (06) :355-365

[16]

Coulton G, 2004, J MOL HISTOL, V35, P603

[17] Integrating high-throughput and computational data elucidates bacterial networks [J].

Covert, MW ;

Knight, EM ;

Reed, JL ;

Herrgard, MJ ;

Palsson, BO .

NATURE, 2004, 429 (6987) :92-96

[18] Interactome: gateway into systems biology [J].

Cusick, ME ;

Klitgord, N ;

Vidal, M ;

Hill, DE .

HUMAN MOLECULAR GENETICS, 2005, 14 :R171-R181

[19] A simple physical model for scaling in protein-protein interaction networks [J].

Deeds, EJ ;

Ashenberg, O ;

Shakhnovich, EI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (02) :311-316

[20] Phylogenomics and the reconstruction of the tree of life [J].

Delsuc, F ;

Brinkmann, H ;

Philippe, H .

NATURE REVIEWS GENETICS, 2005, 6 (05) :361-375

← 1 2 3 4 5 6 7 8 9 10 →