Translational Bioinformatics: Coming of Age

被引:73
作者
Butte, Atul J. [1 ,2 ]
机构
[1] Stanford Univ, Sch Med, Stanford Ctr Biomed Informat, Dept Med, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA
关键词
D O I
10.1197/jamia.M2824
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
The American Medical Informatics Association (AMIA) recently augmented the scope of its activities to encompass translational bioinformatics as a third major domain of informatics. The AMIA has defined translational bioinformatics as "... the development of storage, analytic, and interpretive methods to optimize the transformation of increasingly voluminous biomedical data into proactive, predictive, preventative, and participatory health." In this perspective, I will list eight reasons why this is an excellent time to be Studying translational bioinformatics, including the significant increase in funding opportunities available for informatics from the United States National Institutes of Health, and the explosion Of publicly-available data sets of molecular measurements. I end with the significant challenges we face in building a community of future investigators in Translational Bioinformatics.
引用
收藏
页码:709 / 714
页数:6
相关论文
共 45 条
[31]   GenePattern 2.0 [J].
Reich, M ;
Liefeld, T ;
Gould, J ;
Lerner, J ;
Tamayo, P ;
Mesirov, JP .
NATURE GENETICS, 2006, 38 (05) :500-501
[32]   National Center for Biomedical Ontology: Advancing biomedicine through structured organization of scientific knowledge [J].
Rubin, Daniel L. ;
Lewis, Suzanna E. ;
Mungall, Chris J. ;
Misra, Sima ;
Westerfield, Monte ;
Ashburner, Michael ;
Sim, Ida ;
Chute, Christopher G. ;
Solbrig, Harold ;
Storey, Margaret-Anne ;
Smith, Barry ;
Day-Richter, John ;
Noy, Natalya F. ;
Musen, Mark A. .
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2006, 10 (02) :185-198
[33]   TM4 microarray software suite [J].
Saeed, Alexander I. ;
Hagabati, Nirmal K. ;
Braisted, John C. ;
Liang, Wei ;
Sharov, Vasily ;
Howe, Eleanor A. ;
Li, Jianwei ;
Thiagarajan, Mathangi ;
White, Joseph A. ;
Quackenbush, John .
DNA MICROARRAYS, PART B: DATABASES AND STATISTICS, 2006, 411 :134-+
[34]   QUANTITATIVE MONITORING OF GENE-EXPRESSION PATTERNS WITH A COMPLEMENTARY-DNA MICROARRAY [J].
SCHENA, M ;
SHALON, D ;
DAVIS, RW ;
BROWN, PO .
SCIENCE, 1995, 270 (5235) :467-470
[35]   Central challenges facing the national clinical research enterprise [J].
Sung, NS ;
Crowley, WF ;
Genel, M ;
Salber, P ;
Sandy, L ;
Sherwood, LM ;
Johnson, SB ;
Catanese, V ;
Tilson, H ;
Getz, K ;
Larson, EL ;
Scheinberg, D ;
Reece, EA ;
Slavkin, H ;
Dobs, A ;
Grebb, J ;
Martinez, RA ;
Korn, A ;
Rimoin, D .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (10) :1278-1287
[36]   The minimum information about a proteomics experiment (MIAPE) [J].
Taylor, Chris F. ;
Paton, Norman W. ;
Lilley, Kathryn S. ;
Binz, Pierre-Alain ;
Julian, Randall K., Jr. ;
Jones, Andrew R. ;
Zhu, Weimin ;
Apweiler, Rolf ;
Aebersold, Ruedi ;
Deutsch, Eric W. ;
Dunn, Michael J. ;
Heck, Albert J. R. ;
Leitner, Alexander ;
Macht, Marcus ;
Mann, Matthias ;
Martens, Lennart ;
Neubert, Thomas A. ;
Patterson, Scott D. ;
Ping, Peipei ;
Seymour, Sean L. ;
Souda, Puneet ;
Tsugita, Akira ;
Vandekerckhove, Joel ;
Vondriska, Thomas M. ;
Whitelegge, Julian P. ;
Wilkins, Marc R. ;
Xenarios, Ioannnis ;
Yates, John R., III ;
Hermjakob, Henning .
NATURE BIOTECHNOLOGY, 2007, 25 (08) :887-893
[37]   Significance analysis of microarrays applied to the ionizing radiation response [J].
Tusher, VG ;
Tibshirani, R ;
Chu, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) :5116-5121
[38]   Research policy: The map man [J].
Wadman, Meredith .
NATURE, 2007, 448 (7152) :406-407
[39]  
WALLER D, 2006, TOO LITTLE BANG BUCK
[40]  
Wellcome Trust, 2003, SHAR DAT LARG SCAL B