Synthesis of the First Calix[6]crypturea via a Versatile Tris-azide Precursor

被引：40

作者：

Menand, Mickael ^{[1
]}

Jabin, Ivan ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Chim Organ Lab, B-1050 Brussels, Belgium

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 03期

关键词：

HOST-GUEST PROPERTIES; NEUTRAL GUESTS; HETERODITOPIC RECEPTORS; EFFICIENT SYNTHESIS; CLICK CHEMISTRY; BINDING; SUBSTITUENTS;

D O I：

10.1021/ol8027384

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various nitrogenous calix[6]arene based receptors have been synthesized in one step from a new C-3v symmetrical calix[6]arene intermediate decorated with azido groups. Hence, the first calix[6]crypturea has been obtained in high yield through a unique one-pot process consisting of a domino Staudinger/aza-Wittig reaction followed by a [1 + 1] macrocyclization reaction with a tripodal amine. The conformational properties and some of the host-guest properties of the new calix[6]arene derivatives have been studied by NMR spectroscopy.

引用

页码：673 / 676

页数：4

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