学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

Reduction of thrombogenicity of PVC-based sodium selective membrane electrodes using heparin-modified chitosan

被引：18
作者：
Badr, Ibrahim H. A. [1 ]
Gouda, M. [2 ]
Abdel-Sattar, R. [1 ]
Sayour, Hossam E. M. [3 ]
机构：
[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo 11566, Egypt
[2] Natl Res Ctr, Textile Res Div, Cairo 12311, Egypt
[3] Anim Hlth Res Inst, Dept Chem & Nutr Deficiency Dis, Cairo, Egypt
来源：
CARBOHYDRATE POLYMERS | 2014年 / 99卷
关键词：
Membrane electrodes; Chitosan; Heparin-modified chitosan; Ion-selective electrodes; Biocompatibility; BLOOD COMPATIBILITY; ION SENSORS; PHYSICOCHEMICAL PROPERTIES; POTENTIOMETRIC PROPERTIES; OPTICAL SENSORS; FILMS; POLYURETHANE; POLYMERS; MATRICES; BIOCOMPATIBILITY;
D O I：
10.1016/j.carbpol.2013.08.087
中图分类号：
O69 [应用化学];
学科分类号：
070301 [无机化学];
摘要：
Heparin-modified chitosan (H-chitosan) membrane was utilized to enhance biocompatibility of sodium selective membrane electrode based on the highly thrombogenic polyvinyl chloride (PVC). Sodium ion sensing film was prepared using PVC, sodium ionophore-X, potassium tetrakis(chlorophenyl)-borate, and o-nitrophenyloctylether. The PVC-based sensing film was sandwiched to chitosan or H-chitosan to prevent platelet adhesion on the surface of PVC. Potentiometric response characteristics of PVC-chitosan and PVC-H-chitosan membrane electrodes were found to be comparable to that of a control PVC based sodium-selective electrode. This indicates that chitosan and H-chitosan layers do not alter the response behaviour of the PVC-based sensing film. Biocompatibility of H-chitosan was confirmed by in vitro platelet adhesion study. The platelet adhesion investigations indicated that H-chitosan film is less thrombogenic compared to PVC, which could result in enhancement of biocompatibility of sodium selective membrane electrodes based on PVC, while maintaining the overall electrochemical performance of the PVC-based sensing film. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：783 / 790
页数：8
相关论文
共 63 条
[1]
Characterization of photopolymerized decyl methacrylate as a membrane matrix for ion-selective electrodes [J].
Ambrose, TM ;
Meyerhoff, ME .
ELECTROANALYSIS, 1996, 8 (12) :1095-1100
[2]
PERMEABILITY AND BLOOD COMPATIBILITY PROPERTIES OF CHITOSAN-POLY(ETHYLENE OXIDE) BLEND MEMBRANES FOR HEMODIALYSIS [J].
AMIJI, MM .
BIOMATERIALS, 1995, 16 (08) :593-599
[3]
Response behavior of sodium-selective electrodes modified by surface attachment of the anticoagulant polysaccharides heparin and chondroitin sulfate [J].
Badr, IHA ;
Feiler, J ;
Bachas, LG .
TALANTA, 2005, 65 (01) :261-266
[4]
Ion sensors: current limits and new trends [J].
Bakker, E ;
Diamond, D ;
Lewenstam, A ;
Pretsch, E .
ANALYTICA CHIMICA ACTA, 1999, 393 (1-3) :11-18
[5]
Selectivity of potentiometric ion sensors [J].
Bakker, E ;
Pretsch, E ;
Bühlmann, P .
ANALYTICAL CHEMISTRY, 2000, 72 (06) :1127-1133
[6]
Low heparinization with heparin-bonded bypass circuits: Is it a safe strategy? [J].
Bannan, S ;
Danby, A ;
Cowan, D ;
Ashraf, S ;
Martin, PG .
ANNALS OF THORACIC SURGERY, 1997, 63 (03) :663-668
[7]
Improving the blood compatibility of ion-selective electrodes by employing poly(MPC-co-BMA), a copolymer containing phosphorylcholine, as a membrane coating [J].
Berrocal, MJ ;
Johnson, RD ;
Badr, IHA ;
Liu, MD ;
Gao, DY ;
Bachas, LG .
ANALYTICAL CHEMISTRY, 2002, 74 (15) :3644-3648
[8]
Reducing the thrombogenicity of ion-selective electrode membranes through the use of a silicone-modified segmented polyurethane [J].
Berrocal, MJ ;
Badr, IHA ;
Gao, DO ;
Bachas, LG .
ANALYTICAL CHEMISTRY, 2001, 73 (21) :5328-5333
[9]
CHITOSAN AND MODIFIED CHITOSAN MEMBRANES .1. PREPARATION AND CHARACTERIZATION [J].
BLAIR, HS ;
GUTHRIE, J ;
LAW, TK ;
TURKINGTON, P .
JOURNAL OF APPLIED POLYMER SCIENCE, 1987, 33 (02) :641-656
[10]
PHOTOCURABLE POLYMER MATRICES FOR POTASSIUM-SENSITIVE ION-SELECTIVE ELECTRODE MEMBRANES [J].
BRATOV, A ;
ABRAMOVA, N ;
MUNOZ, J ;
DOMINGUEZ, C ;
ALEGRET, S ;
BARTROLI, J .
ANALYTICAL CHEMISTRY, 1995, 67 (19) :3589-3595
1234567