Role of tau protein in both physiological and pathological conditions

被引:726
作者
Avila, J [1 ]
Lucas, JJ [1 ]
Pérez, M [1 ]
Hernández, F [1 ]
机构
[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
关键词
D O I
10.1152/physrev.00024.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated protein that stabilizes neuronal microtubules under normal physiological conditions. However, in certain pathological situations, tau protein may undergo modifications, mainly through phosphorylation, that can result in the generation of aberrant aggregates that are toxic to neurons. This process occurs in a number of neurological disorders collectively known as tauopathies, the most commonly recognized of which is Alzheimer's disease. The purpose of this review is to define the role of tau protein under normal physiological conditions and to highlight the role of the protein in different tauopathies.
引用
收藏
页码:361 / 384
页数:24
相关论文
共 311 条
[11]   STRUCTURE AND NOVEL EXONS OF THE HUMAN-TAU GENE [J].
ANDREADIS, A ;
BROWN, WM ;
KOSIK, KS .
BIOCHEMISTRY, 1992, 31 (43) :10626-10633
[12]   ANALYSIS OF PAIRED HELICAL FILAMENTS (PHFS) FOUND IN ALZHEIMERS-DISEASE USING FREEZE-DRYING ROTARY SHADOWING [J].
APPELT, DM ;
BALIN, BJ .
JOURNAL OF STRUCTURAL BIOLOGY, 1993, 111 (02) :85-95
[13]   The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine [J].
Arnold, CS ;
Johnson, GVW ;
Cole, RN ;
Dong, DLY ;
Lee, M ;
Hart, GW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) :28741-28744
[14]   Polymerization of tau peptides into fibrillar structures.: The effect of FTDP-17 mutations [J].
Arrasate, M ;
Pérez, M ;
Armas-Portela, R ;
Avila, J .
FEBS LETTERS, 1999, 446 (01) :199-202
[15]  
Arrasate M, 1997, AM J PATHOL, V151, P1115
[16]   Tau dephosphorylation at tau-1 site correlates with its association to cell membrane [J].
Arrasate, M ;
Pérez, M ;
Avila, J .
NEUROCHEMICAL RESEARCH, 2000, 25 (01) :43-50
[17]   NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].
ARRIAGADA, PV ;
GROWDON, JH ;
HEDLEYWHYTE, ET ;
HYMAN, BT .
NEUROLOGY, 1992, 42 (03) :631-639
[18]   N-t-butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro [J].
Atamna, H ;
Robinson, C ;
Ingersoll, R ;
Elliott, H ;
Ames, BN .
FASEB JOURNAL, 2001, 15 (12) :2196-2204
[19]   Tau function and dysfunction in neurons - Its role in neurodegenerative disorders [J].
Avila, J ;
Lim, F ;
Moreno, F ;
Belmonte, C ;
Cuello, AC .
MOLECULAR NEUROBIOLOGY, 2002, 25 (03) :213-231
[20]  
BAAS PW, 1994, J CELL SCI, V107, P135