Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimer's Disease

被引：12

作者：

Hernandez, Felix ^{[1
]}

Lim, Filip ^{[1
]}

Lucas, Jose J. ^{[1
]}

Perez-Martin, Concepcion ^{[1
]}

Moreno, Franscisco ^{[1
]}

Avila, Jesus ^{[1
]}

机构：

[1] CSIC UAM Madrid, Ctr Biol Mol Severo Ochoa, Madrid, Spain

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 01期

关键词：

D O I：

10.2174/1389557023406557

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The deposit of two proteins in the brain characterizes Alzheimer's disease: deposits of beta-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimer's disease.

引用

页码：51 / 58

页数：8

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