Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine

被引：50

作者：

Sriwilaijareon, N

Petmitr, S

Mutirangura, A

Ponglikitmongkol, M

Wilairat, P

机构：

[1] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok 10400, Thailand

[3] Chulalongkorn Univ, Fac Med, Dept Anat, Bangkok 10400, Thailand

来源：

PARASITOLOGY INTERNATIONAL | 2002年 / 51卷 / 01期

关键词：

Plasmodium falciparum; telomerase; berberine; antimalarial;

D O I：

10.1016/S1383-5769(01)00092-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Telomerase activity in synchronized Plasmodium falciparum during its erythrocytic cycle was examined using the TRAP assay. Telomerase activity was detected at all stages of the parasite intraerythrocyte development, with higher activity in trophozoite and schizont stages compared with ring form. Berberine, extracted from Arcangelisia flava (L.) Merr., inhibited telomerase activity in a dose-dependent manner over a range of 30-300 muM, indicating that P. falciparum telomerase might be a potential target for future malaria chemotherapy. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：99 / 103

页数：5

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