Efficient and practical protocol for silylation of hydroxyl groups using reusable lithium perchlorate dispersed in silica gel under neutral condition

被引：71

作者：

Azizi, N ^{[1
]}

Yousefi, R ^{[1
]}

Saidi, MR ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2006年 / 691卷 / 05期

关键词：

LP-SiO2; silylation; hexamethyldisilazane; recycling; hydroxyl group; regioselective; alcohol; phenol; lithium perchlorate; silica gel;

D O I：

10.1016/j.jorganchem.2005.11.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A very efficient and mild procedure for the trimethylsilylation of a wide variety of alcohols, including primary, allylic, benzylic, secondary, hindered secondary, tertiary, and phenols with hexamethyldisilazane on the surface of silica gel dispersed with LiClO4 in room temperature at few minutes in excellent yields under neutral conditions is reported. This procedure also allows the excellent selectivity under LP-SiO2 system for silylation of alcohols in the presence of amine and phenolic hydroxy groups. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：817 / 820

页数：4

共 26 条

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