Chromosome territories -: a functional nuclear landscape

被引：456

作者：

Cremer, Thomas

Cremer, Marion

Dietzel, Steffen

Mueller, Stefan

Solovei, Irina

Fakan, Stanislav

机构：

[1] Univ Munich, Dept Biol 2, D-82152 Martinsried, Germany

[2] Univ Lausanne, Ctr Electron Microscopy, CH-1005 Lausanne, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 03期

关键词：

D O I：

10.1016/j.ceb.2006.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Understanding nuclear architecture is indispensable for understanding the cell-type-dependent orchestration of active and silent genes and other nuclear functions, such as RNA splicing, DNA replication and repair. Yet, while it is now generally agreed that chromosomes in the cell nucleus are organized as chromosome territories, present models of chromosome territory architecture differ widely with respect to the possible functional implications of dynamic changes of this architecture during the cell cycle and terminal cell differentiation.

引用

页码：307 / 316

页数：10

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