The NMDA receptor as a target for cognitive enhancement

被引：187

作者：

Collingridge, Graham L. ^{[1
,2
]}

Volianskis, Arturas ^{[1
]}

Bannister, Neil ^{[1
]}

France, Grace ^{[1
]}

Hanna, Lydia ^{[1
]}

Mercier, Marion ^{[1
]}

Tidball, Patrick ^{[1
]}

Fang, Guangyu ^{[1
]}

Irvine, Mark W. ^{[1
]}

Costa, Blaise M. ^{[3
]}

Monaghan, Daniel T. ^{[3
]}

Bortolotto, Zuner A. ^{[1
]}

Molnar, Elek ^{[1
]}

Lodge, David ^{[1
]}

Jane, David E. ^{[1
]}

机构：

[1] Univ Bristol, Sch Physiol & Pharmacol, MRC Ctr Synapt Plast, Bristol BS1 3NY, Avon, England

[2] Seoul Natl Univ, Dept Brain & Cognit Sci, Seoul, South Korea

[3] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

来源：

NEUROPHARMACOLOGY | 2013年 / 64卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Synaptic plasticity; NMDA receptor; Cognitive enhancement; LTP; Synaptic transmission; Hippocampus; Positive allosteric modulators; METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; POSITIVE ALLOSTERIC MODULATOR; PROTEIN-KINASE-C; RAT HIPPOCAMPAL SLICES; AMINO-ACID OXIDASE; METABOTROPIC GLUTAMATE RECEPTORS; COLLATERAL-COMMISSURAL PATHWAY; TYROSINE PHOSPHATASE STEP; GLYCINE-BINDING-SITE;

D O I：

10.1016/j.neuropharm.2012.06.051

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

NMDA receptors (NMDARs) play an important role in neural plasticity including long-term potentiation and long-term depression, which are likely to explain their importance for learning and memory. Cognitive decline is a major problem facing an ageing human population, so much so that its reversal has become an important goal for scientific research and pharmaceutical development. Enhancement of NMDAR function is a core strategy toward this goal. In this review we indicate some of the major ways of potentiating NMDAR function by both direct and indirect modulation. There is good evidence that both positive and negative modulation can enhance function suggesting that a subtle approach correcting imbalances in particular clinical situations will be required. Excessive activation and the resultant deleterious effects will need to be carefully avoided. Finally we describe some novel positive allosteric modulators of NMDARs, with some subunit selectivity, and show initial evidence of their ability to affect NMDAR mediated events. This article is part of a Special Issue entitled 'Cognitive Enhancers'. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：13 / 26

页数：14

共 202 条

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SINGLE HIGH-STRENGTH AFFERENT VOLLEYS CAN PRODUCE LONG-TERM POTENTIATION IN THE HIPPOCAMPUS INVITRO [J].