A simple sheath-flow microfluidic device for micro/nanomanufacturing: fabrication of hydrodynamically shaped polymer fibers

被引：73

作者：

Thangawng, Abel L. ^{[1
]}

Howell, Peter B., Jr. ^{[1
]}

Richards, Jeffrey J. ^{[1
]}

Erickson, Jeffrey S. ^{[1
]}

Ligler, Frances S. ^{[1
]}

机构：

[1] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA

来源：

LAB ON A CHIP | 2009年 / 9卷 / 21期

关键词：

MICROFABRICATION; NANOFIBERS;

D O I：

10.1039/b910581f

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple sheath flow microfluidic device is used to fabricate polymer micro/nanofibers that have precisely controlled shapes and sizes. Poly(methylmethacrylate) (PMMA) was used as the model polymer for these experiments. The sheath-flow device uses straight diagonal and chevron-shaped grooves integrated in the top and bottom walls of the flow channel to move sheath fluid completely around the polymer stream. Portions of the sheath stream are deflected in such a way as to define the cross-sectional shape of the polymer core. The flow-rate ratio between the sheath and core solution determines the fiber diameter. Round PMMA fibers with a diameter as small as 300 nm and flattened fibers with a submicron thickness are demonstrated.

引用

页码：3126 / 3130

页数：5

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