CTLA4 gene polymorphism and autoimmunity

被引：220

作者：

Gough, SCL

Walker, LSK

Sansom, DM

机构：

[1] Univ Birmingham, Inst Biomed Res, Div Med Sci, Birmingham B9 5SS, W Midlands, England

[2] Univ Birmingham, Inst Biomed Res, MRC, Ctr Immune Regulat, Birmingham B9 5SS, W Midlands, England

来源：

IMMUNOLOGICAL REVIEWS | 2005年 / 204卷

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.0105-2896.2005.00249.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4) are two receptors that have critical but opposing functions in T-cell stimulation. CD28 promotes a number of T-cell activities, whereas in contrast CTLA4 is an essential inhibitor of T-cell responses. Because of its inhibitory role, CTLA4 is a strong candidate susceptibility gene in autoimmunity and several studies suggest disease-associated polymorphisms. In this review, we discuss recent progress in relating CTLA4 polymorphisms to disease susceptibility and consider the putative mechanisms by which CTLA4 may act to inhibit autoimmunity.

引用

页码：102 / 115

页数：14

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