Hepatic MR imaging using ferumoxides: Prospective evaluation with surgical and intraoperative sonographic confirmation in 25 cases

被引:16
作者
Raman, SS
Lu, DSK
Chen, SC
Sayre, J
Eilber, F
Economou, J
机构
[1] Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA
关键词
D O I
10.2214/ajr.177.4.1770807
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OBJECTIVE. The purpose of our study was to evaluate the sensitivity and accuracy of ferumoxides-enhanced MR imaging in comparison with surgery and intraoperative sonography. SUBJECTS AND METHODS. We prospectively evaluated 25 consecutive studies in 24 patients who underwent ferumoxides-enhanced hepatic MR imaging before surgery and intraoperative sonography. Both 1.5-T scanners (13 cases) and 0.2-T scanners (12 cases) were used. Turbo spin-echo T2-weighted sequences were performed before and after the administration of ferumoxides and the images were compared. Lesions were classified as solid or nonsolid and tabulated on standard liver maps. The Ever maps from MR ima-mia were compared with those from surgery and intraoperative sonography. For lesions greater than 1 cm, the regions of interest were measured and contrast-to-noise ratio was calculated. RESULTS. Of 93 solid lesions found at surgery, 69 were seen on unenhanced MR imaging (sensitivity, 74.2%) and 87 were seen on ferumoxides-enhanced MR imaging (sensitivity, 93.5%) (p < 0.05). Of the seven benign lesions (five cysts, two hemangiomas) found at surgery, all were correctly identified as benign on MR imaging. Two lesions identified as solid before surgery were not found at surgery. Mean lesion contrast-to-noise ratio for the unenhanced scans was 22.9 and 34.5 (p < 0.001) for the ferumoxides-enhanced scans. Subanalysis of 1.5- and 0.2-T MR imaging revealed similar results with significant (p < 0.05) increases in sensitivity for both. The average size of the lesions missed before surgery was 0.7 cm. CONCLUSION. Turbo spin-echo T2-weighted ferumoxides-enhanced MR imaging at either 1.5 or 0.2 T has value in preoperative liver assessment.
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收藏
页码:807 / 812
页数:6
相关论文
共 28 条
[1]  
[Anonymous], 1990, ANN SURG, V211, P277
[2]   LIVER METASTASES - SAFETY AND EFFICACY OF DETECTION WITH SUPERPARAMAGNETIC IRON-OXIDE IN MR-IMAGING [J].
BELLIN, MF ;
ZAIM, S ;
AUBERTON, E ;
SARFATI, G ;
DURON, JJ ;
KHAYAT, D ;
GRELLET, J .
RADIOLOGY, 1994, 193 (03) :657-663
[3]   Detection of hepatic lesions in candidates for surgery: Comparison of ferumoxides-enhanced MR imaging and dual-phase helical CT [J].
Bluemke, DA ;
Paulson, EK ;
Choti, MA ;
DeSena, S ;
Clavien, PA .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2000, 175 (06) :1653-1658
[4]   The influence of MR field strength on the detection of focal liver lesions with superparamagnetic iron oxide [J].
Deckers, F ;
Corthouts, B ;
Nackaerts, Y ;
Ozsarlak, O ;
Parizel, PM ;
DeSchepper, AM .
EUROPEAN RADIOLOGY, 1997, 7 (06) :887-892
[5]   HEPATIC TUMORS - DETECTION AND CHARACTERIZATION AT 1-T MR-IMAGING ENHANCED WITH AMI-25 [J].
DENYS, A ;
ARRIVE, L ;
SERVOIS, V ;
DUBRAY, B ;
NAJMARK, D ;
SIBERT, A ;
MENU, Y .
RADIOLOGY, 1994, 193 (03) :665-669
[6]   HEPATOCELLULAR-CARCINOMA [J].
DIBISCEGLIE, AM ;
RUSTGI, VK ;
HOOFNAGLE, JH ;
DUSHEIKO, GM ;
LOTZE, MT .
ANNALS OF INTERNAL MEDICINE, 1988, 108 (03) :390-401
[7]   Minimally invasive treatment of malignant hepatic tumors: At the threshold of a major breakthrough [J].
Dodd, GD ;
Soulen, MC ;
Kane, RA ;
Livraghi, T ;
Lees, WR ;
Yamashita, Y ;
Gillams, AR ;
Karahan, OI ;
Rhim, H .
RADIOGRAPHICS, 2000, 20 (01) :9-27
[8]   AN AMERICANS GUIDE TO COUINAUD NUMBERING SYSTEM [J].
DODD, GD .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1993, 161 (03) :574-575
[9]   Advances in abdominal MR imaging [J].
Ferrucci, JT .
RADIOGRAPHICS, 1998, 18 (06) :1569-1586
[10]   Liver resection for colorectal metastases [J].
Fong, YM ;
Cohen, AM ;
Fortner, JG ;
Enker, WE ;
Turnbull, AD ;
Coit, DG ;
Marrero, AM ;
Prasad, M ;
Blumgart, LH ;
Brennan, MF .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (03) :938-946