Lathyranoic acid A:: First secolathyrane diterpenoid in nature from Euphorbia lathyris

被引：50

作者：

Liao, SG ^{[1
]}

Zhan, ZJ ^{[1
]}

Yang, SP ^{[1
]}

Yue, JM ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 07期

关键词：

D O I：

10.1021/ol050206a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lathyranoic acid A (1), the first secolathyrane diterpenoid with an unprecedented skeleton, and a new diterpenoid Euphorbia factor L-11 (2) were isolated from the seeds of Euphorbia lathyris. Their structures were elucidated by spectroscopic analysis and chemical methods. A biogenetic route involving an enzymatic Baeyer-Villiger oxidation as the key step was postulated for the transformation of 2 to 1 and mimicked by an unusual chemical Baeyer-Villiger oxidation.

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页码：1379 / 1382

页数：4

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