Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs

被引：31

作者：

Huikko, K

Östman, P

Sauber, C

Mandel, F

Grigoras, K

Franssila, S

Kotiaho, T

Kostiainen, R

机构：

[1] Univ Helsinki, Viikki Drug Discovery Technol Ctr, DDTC, Dept Pharm, FIN-00014 Helsinki, Finland

[2] Agilent Technol, Deutschland GmbH, D-76337 Waldbronn, Germany

[3] Aalto Univ, Ctr Microelect, FIN-02015 Helsinki, Finland

[4] Univ Helsinki, Div Pharmaceut Chem, Dept Pharm, FIN-00014 Helsinki, Finland

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 2003年 / 17卷 / 12期

关键词：

D O I：

10.1002/rcm.1051

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) for drug analysis was investigated. It was observed that only compounds with relative high proton affinity are efficiently ionized under AP-DIOS conditions. The limits of detection (LODs) achieved in MS mode with midazolam, propranolol, and angiotensin II were 80fmol, 20 pmol, and 1 pmol, respectively. In MS/MS mode the LODs for midazolam, and propranolol were 10fmol and 5pmol, respectively. The good linearity (r(2) > 0.991), linear dynamic range of 3 orders of magnitude, and reasonable repeatability showed that the method is suitable for quantitative analysis. Copyright (C) 2003 John Wiley Sons, Ltd.

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页码：1339 / 1343

页数：5

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