The use of borane-amine adducts as versatile palladium-catalyzed hydrogen-transfer reagents in methanol

被引：32

作者：

Couturier, M ^{[1
]}

Andresen, BM ^{[1
]}

Tucker, JL ^{[1
]}

Dubé, P ^{[1
]}

Brenek, SJ ^{[1
]}

Negri, JT ^{[1
]}

机构：

[1] Pfizer Inc, Global Res & Dev, Chem Res & Dev, Groton, CT 06340 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(01)00300-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The scope of borane-amine adducts as reducing agents is broadened through palladium-catalyzed methanolysis capable of reducing a wide variety of functional groups. Hence, borane mediated reduction of a benzamide followed by a tandem methanolysis/hydrogenolysis of the resulting borane-benzylamine adduct allows chemoselective removal of an N-benzoyl in the presence of an O-benzoyl. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2763 / 2766

页数：4

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