A forward-genetic approach for analysis of the immune system

被引：15

作者：

Appleby, MW ^{[1
]}

Ramsdell, F ^{[1
]}

机构：

[1] Celltech R & D Inc, Discovery Biol, Bothell, WA 98021 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1038/nri1109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The completion of the genome sequences of both humans and mice challenges biologists to determine gene function on a vast, whole-organism scale. Both phenotype-based ('forward') and gene-based ('reverse') strategies are being developed to approach this issue. Forward-genetic approaches, however, provide the unique ability of assigning function to genes in an unbiased, global manner that is independent of previous assumptions about gene function. In this article, we compare various genetic technologies for their potential role in dissecting immune-system development and function, with particular emphasis on the worldwide efforts that use chemical mutagenesis as a forward-genetic strategy.

引用

页码：463 / 471

页数：9

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