The first conversion of camptothecin to (S)-mappicine by an efficient chemoenzymatic method

被引：26

作者：

Das, B ^{[1
]}

Madhusudhan, P ^{[1
]}

Kashinatham, A ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(98)00234-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Camptothecin has been converted for the first time to (S)-mappicine via mappicine ketone, which is the sole product of the microwave irradiation cf camptothecin. Baker's yeast reduction of mappicine ketone yielded (S)-mappicine in high optical purity, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1403 / 1406

页数：4

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