Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants

被引：149

作者：

Lacaille-Dubois, MA

Franck, U

Wagner, H

机构：

[1] Univ Bourgogne, Fac Pharm, Lab Pharmacognosie, Unite Mol Interet Biol, F-21079 Dijon, France

[2] Univ Munich, Pharma Res Ctr, Munich, Germany

来源：

PHYTOMEDICINE | 2001年 / 8卷 / 01期

关键词：

Musanga cecropioides; Cecropia species and Crataegus oxyacantha/C. monogyna; angiotensin converting enzyme; ACE; hypotensive agents; flavonoids; procyanidins;

D O I：

10.1078/0944-7113-00003

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

MeOH extracts, fractions and pure substances from Musanga cecropioides, Cecropia species and Crataegus oxyacantha /C. monogyna were screened by using an in vitro bio-assay based on the inhibition of Angiotensin Converting Enzyme (ACE), as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. Phenolic acids showed no significant ACE-inhibition whereas flavonoids and proanthocyanidins demonstrated inhibitory activity at 0.33 mg/ml using this test system.

引用

页码：47 / 52

页数：6

共 16 条

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ARISAWA M, 1989, Shoyakugaku Zasshi, V43, P78

[2]

A NEW METHOD FOR THE INVITRO SCREENING OF INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME (ACE), USING THE CHROMOPHORE-LABELED AND FLUOROPHORE-LABELED SUBSTRATE, DANSYLTRIGLYCINE [J].