Glioma stem cells: A midterm exam

被引：243

作者：

Stiles, Charles D. ^{[1
,2
]}

Rowitch, David H. ^{[3
,4
,5
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Pediat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Neurol Surg, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Inst Regenerat Med, San Francisco, CA 94143 USA

来源：

NEURON | 2008年 / 58卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2008.05.031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several years ago, the discovery of a highly tumorigenic subpopulation of stem-like cells embedded within fresh surgical isolates of malignant gliomas lent support to a new paradigm in cancer biology-the cancer stem cell hypothesis. At the same time, these "glioma stem cells" seemed to resolve a long-standing conundrum on the cell of origin for primary cancers of the brain. However, central tenets of the cancer stem cell hypothesis have recently been challenged, and the cellular origins of stem-like cells within malignant glioma are still contended. Here, we summarize the issues that are still in play with respect to the cancer stem cell hypothesis, and we revisit the developmental origins of malignant glioma. Do glioma stem cells arise from developmentally stalled neural progenitors or from dedifferentiated astrocytes? Five separate predictions of a neural progenitor cell of origin are put to the test. © 2008 Elsevier Inc. All rights reserved.

引用

页码：832 / 846

页数：15

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