Cross-Coupling of Aryllithiums with Aryl and Vinyl Halides in Flow Microreactors

被引：28

作者：

Nagaki, Aiichiro ^{[1
]}

Moriwaki, Yuya ^{[1
]}

Haraki, Suguru ^{[1
]}

Kenmoku, Akira ^{[2
]}

Takabayashi, Naofumi ^{[1
]}

Hayashi, Atsushi ^{[1
]}

Yoshida, Jun-Ichi ^{[1
]}

机构：

[1] Kyoto Univ, Dept Synthet & Biol Chem, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan

[2] Res Assoc Micro Chem Proc Technol MCPT, Nishikyo Ku, Kyoto 6158510, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2012年 / 7卷 / 05期

关键词：

arenes; cross-coupling; halides; lithiation; microreactors; ORGANIC-SYNTHESIS; GRIGNARD-REAGENTS; ORGANOLITHIUM COMPOUNDS; MICROFLOW SYSTEMS; CAPILLARY-MICROREACTOR; ALKOXYCARBONYL GROUPS; CHEMICAL-REACTIONS; SPACE INTEGRATION; BIARYL SYNTHESIS; IONIC LIQUID;

D O I：

10.1002/asia.201101019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of Pd catalysts that contained a carbene ligand, such as PEPPSI-SIPr, speeded up the Murahashi coupling of ArLi with ArBr, by enabling its integration with the Br/Li exchange of ArBr with BuLi in flow. Space integration realized the rapid cross-coupling of two different ArBr substrates. However, the cross-coupling reaction with vinyl halides could not be achieved under similar conditions. Pd(OAc)2 was an effective catalyst, and the space integration of the Br/Li exchange of ArBr with BuLi and the Murahashi coupling with vinyl halides was successfully achieved.

引用

页码：1061 / 1068

页数：8

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