Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides

被引：116

作者：

Koshkin, AA ^{[1
]}

Rajwanshi, VK ^{[1
]}

Wengel, J ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Chem, Chem Lab 2, DK-2100 Copenhagen, Denmark

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(98)00706-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

LNA (Locked Nucleic Acids) is a novel oligonucleotide analogue containing [2.2.1]bicyclo nucleoside monomers. A novel and significantly improved method for convergent synthesis of LNA [2.2.1]bicyclo nucleosides using a 4-C-tosyloxymethyl-1,2-di-O-acetyl furanose as a key synthon is described. In addition, an alternative, robust linear approach allowing selective formation of the desired [2.2.1]bicyclo LNA nucleosides via a tricyclic nucleoside intermediate is introduced. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4381 / 4384

页数：4

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