LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

被引：704

作者：

Singh, SK

Nielsen, P

Koshkin, AA

Wengel, J

机构：

[1] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark

[2] Odense Univ, Dept Chem, DK-5230 Odense M, Denmark

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 04期

关键词：

D O I：

10.1039/a708608c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson-Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.

引用

页码：455 / 456

页数：2

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