Synthesis of highly substituted tetrahydropyrans: preparation of the C20-C28 moiety of phorboxazoles

被引：23

作者：

Chakraborty, TK ^{[1
]}

Reddy, VR ^{[1
]}

Reddy, TJ ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Bioorgan Lab, Organ Div 3, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2003年 / 59卷 / 43期

关键词：

epoxy alcohols; Sharpless epoxidation; epoxide opening; 2-methyl-1,3-diol; phorboxazoles;

D O I：

10.1016/j.tet.2003.08.056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A propionate-derived polyketide building block A whose 2-methyl-1,3-diol moiety was built by a Ti(III)-mediated ring opening reaction of a trisubstituted 2,3-epoxy alcohol precursor was employed as a common starting material for the syntheses of highly substituted tetrahydropyrans 1-5, the first one being the C20-C28 fragment of cytotoxic natural products, phorboxazoles. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：8613 / 8622

页数：10

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