Synthesis and biological evaluation of substituted quinolines:: Potential treatment of protozoal and retroviral co-infections

被引：196

作者：

Fakhfakh, MA

Fournet, A

Prina, E

Mouscadet, JF

Franck, X

Hocquemiller, R

Figadère, B

机构：

[1] Univ Paris Sud, Fac Pharm, Lab Pharmacognosie, CNRS BioCIS, F-92296 Chatenay Malabry, France

[2] Inst Rech Dev, F-75480 Paris, France

[3] Inst Pasteur, Unite Immunophysiol & Parasitisme Intracellulaire, F-75724 Paris 15, France

[4] Inst Gustave Roussy, URA 147 CNRS, PRII, Lab Physicochim & Pharmacol Macromol Biol, F-94805 Villejuif, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 23期

关键词：

D O I：

10.1016/j.bmc.2003.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：5013 / 5023

页数：11

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