Regioselective reduction of N-alkyl-3-sulfonyl glutarimides to δ-lactams.: Formal synthesis of (±)-paroxetine and (±)-tacamonine

被引：18

作者：

Chen, CY

Chang, BR

Tsai, MR

Chang, MY

Chang, NC ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[2] Natl Univ Kaohsiung, Dept Appl Chem, Kaohsiung 811, Taiwan

来源：

TETRAHEDRON | 2003年 / 59卷 / 47期

关键词：

glutarimide delta-lactam; regioselective reduction; paroxetine; tacamonine;

D O I：

10.1016/j.tet.2003.09.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the preparation of 4- or 5-substituted 3-sulfonyl-delta-lactams via regioselective reduction of N-alkyl-3-sulfonyl glutarimides is described. Formal synthesis of (+/-)-paroxetine and (+/-)-tacamonine is also reported. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：9383 / 9387

页数：5

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