A Clean and One-Pot Synthesis of Spiroindoline-Pyranopyrazoles

被引：48

作者：

Ahadi, Somayeh ^{[1
]}

Yasaei, Zahra ^{[1
]}

Bazgir, Ayoob ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran 1983963113, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 05期

关键词：

MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; SPIRO-HETEROCYCLES; 3-COMPONENT; SPIROOXINDOLES; DERIVATIVES; FLUORINE; FACILE;

D O I：

10.1002/jhet.437

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Piperidine catalyzes efficiently the one-pot, four-component reaction of beta-ketoesters, hydrazine hydrate, malononitrile, and isatines in aqueous media. The reaction was done at room temperature and the spiro[indoline-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitriles were obtained with high yields and purity via an easy work-up procedure. These compounds were also investigated in vitro for antibacterial activities.

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页码：1090 / 1094

页数：5

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