Delivering growth factors for therapeutics

被引：169

作者：

Anitua, Eduardo ^{[1
]}

Sanchez, Mikel ^{[2
]}

Orive, Gorka ^{[1
]}

Andia, Isabel ^{[1
]}

机构：

[1] Biotechnol Inst I MAS, Victoria 01005, Spain

[2] Unidad Cirugia Arthoscop Mikel Sanchez, Victoria 01005, Spain

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2008年 / 29卷 / 01期

关键词：

D O I：

10.1016/j.tips.2007.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The method by which a drug is released can have a significant effect on therapeutic efficacy. The mode of drug delivery is especially relevant when the therapeutic agent is a growth factor because the dose and spatiotemporal release of such agents at the site of injury is crucial to achieving a successful outcome. Here, we highlight delivery technologies designed to facilitate the local and controlled spatiotemporal release of growth factors through the use of biomaterials, 3D micro- or nano-particles, microspheres, gene therapy and PRGF technology. We present some of the most interesting therapeutic applications based on these approaches and, on PRGF technology in particular, in addition to the limitations, future challenges and directions of the field.

引用

收藏

页码：37 / 41

页数：5

相关论文

共 53 条

[21] THE POTENTIAL ROLE OF PLATELET-DERIVED GROWTH-FACTOR AS AN AUTOCRINE OR PARACRINE FACTOR FOR HUMAN-BONE CELLS [J].

GRAVES, DT ;

VALENTINOPRAN, A ;

DELGADO, R ;

VALENTE, AJ ;

MUNDY, G ;

PICHE, J .

CONNECTIVE TISSUE RESEARCH, 1989, 23 (2-3) :209-218

[22] Vascular endothelial growth factor in ischemia for vascular angiogenesis [J].

Henry, TD ;

Annex, BH ;

McKendall, GR ;

Azrin, MA ;

Lopez, JJ ;

Giordano, FJ ;

Shah, PK ;

Willerson, JT ;

Benza, RL ;

Berman, DS ;

Gibson, CM ;

Bajamonde, A ;

Rundle, AC ;

Fine, J ;

McCluskey, ER .

CIRCULATION, 2003, 107 (10) :1359-1365

[23] Effects of growth factors and cytokines on osteoblast differentiation [J].

Hughes, FJ ;

Turner, W ;

Belibasakis, G ;

Martuscelli, G .

PERIODONTOLOGY 2000, 2006, 41 :48-72

[24] Chitosan hydrogel as a drug delivery carrier to control angiogenesis [J].

Ishihara M. ;

Obara K. ;

Nakamura S. ;

Fujita M. ;

Masuoka K. ;

Kanatani Y. ;

Takase B. ;

Hattori H. ;

Morimoto Y. ;

Ishihara M. ;

Maehara T. ;

Kikuchi M. .

Journal of Artificial Organs, 2006, 9 (1) :8-16

[25] Formation of dentin-like particles in dentin defects above exposed pulp by controlled release of fibroblast growth factor 2 from gelatin hydrogels [J].

Kikuchi, Naoki ;

Kitamura, Chiaki ;

Morotomi, Takahiko ;

Inuyama, Yoshio ;

Ishimatsu, Hirotaka .

JOURNAL OF ENDODONTICS, 2007, 33 (10) :1198-1202

[26] Transplantation of culture expanded bone marrow cells and platelet rich plasma in distraction osteogenesis of the long bones [J].

Kitoh, Hiroshi ;

Kitakoji, Takahiko ;

Tsuchlya, Hiroki ;

Katoh, Mitsuyasu ;

Ishiguro, Naoki .

BONE, 2007, 40 (02) :522-528

[27] Designing materials for biology and medicine [J].

Langer, R ;

Tirrell, DA .

NATURE, 2004, 428 (6982) :487-492

[28] Controlled growth factor release from synthetic extracellular matrices [J].

Lee, KY ;

Peters, MC ;

Anderson, KW ;

Mooney, DJ .

NATURE, 2000, 408 (6815) :998-1000

[29] Platelet-derived growth factors enhance proliferation of human stromal stem cells [J].

Lucarelli, E ;

Beccheroni, A ;

Donati, D ;

Sangiorgi, L ;

Cenacchi, A ;

Del Vento, AM ;

Meotti, C ;

Bertoja, AZ ;

Giardino, R ;

Fornasari, PM ;

Mercuri, M ;

Picci, P .

BIOMATERIALS, 2003, 24 (18) :3095-3100

[30] Endogenous TGF-β signaling suppresses maturation of osteoblastic mesenchymal cells [J].

Maeda, S ;

Hayashi, M ;

Komiya, S ;

Imamura, T ;

Miyazono, K .

EMBO JOURNAL, 2004, 23 (03) :552-563

← 1 2 3 4 5 6 →