Solubility of glycine polymorphs and recrystallization of β-glycine

被引：53

作者：

Bouchard, Andreanne ^{[1
]}

Hofland, Gerard W. ^{[1
]}

Witkamp, Geert-Jan ^{[1
]}

机构：

[1] Delft Univ Technol, NL-2628 CA Delft, Netherlands

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2007年 / 52卷 / 05期

关键词：

AMINO-ACIDS; CRYSTALLIZATION; DIGLYCINE;

D O I：

10.1021/je700014k

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubilities of alpha-, beta-, and gamma-glycine in aqueous solutions containing methanol, ethanol, 2-propanol, or acetone were measured at 3 10 K. The solubility of all the polymorphs dropped rapidly as a function of the concentration of antisolvent. The solubility of the glycine polymorphs in water-anti solvent mixtures was, in decreasing order: methanol > ethanol > 2-propanol > acetone. The solubility of alpha-glycine was slightly higher than that of gamma-glycine, but the solubility of beta-glycine was significantly higher by up to 17 %. The induction time for the recrystallization of beta- to alpha-glycine in those water-anti solvent mixtures was, in decreasing order: methanol > ethanol > acetone > 2-propanol. This signifies that the selection of an antisolvent for preparation of beta-glycine can have an important effect on the product.

引用

页码：1626 / 1629

页数：4

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