Vascularization is the key challenge in tissue engineering

被引:792
作者
Novosel, Esther C. [1 ]
Kleinhans, Claudia [1 ]
Kluger, Petra J. [1 ,2 ]
机构
[1] Univ Stuttgart, Inst Interfacial Engn, D-70569 Stuttgart, Germany
[2] Fraunhofer Inst Interfacial Engn & Biotechnol, Dept Cell & Tissue Engn, D-70569 Stuttgart, Germany
关键词
Neovascularization; Angiogenesis; Scaffolds; Endothelial cells; Growth factors; Rapid prototyping; Nutrient supply; Regenerative medicine; ENDOTHELIAL PROGENITOR CELLS; ANGIOGENIC GROWTH-FACTOR; SMALL INTESTINAL SUBMUCOSA; ARTERIOVENOUS SHUNT LOOP; IN-VITRO; STEM-CELLS; PHENOTYPIC HETEROGENEITY; MICROVASCULAR NETWORKS; MYOCARDIAL-INFARCTION; AXIAL VASCULARIZATION;
D O I
10.1016/j.addr.2011.03.004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel system the vascularization. In vivo almost all tissues are supplied by these endothelial cell coated tubular networks. Current strategies to create vascularized tissues are discussed in this review. The first strategy is based on the endothelial cells and their ability to form new vessels known as neoangiogenesis. Herein prevascularization techniques are compared to approaches in which biomolecules, such as growth factors, cytokines, peptides and proteins as well as cells are applied to generate new vessels. The second strategy is focused on scaffold-based techniques. Naturally-derived scaffolds, which contain vessels, are distinguished from synthetically manufactured matrices. Advantages and pitfalls of the approaches to create vascularized tissues in vitro are outlined and feasible future strategies are discussed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:300 / 311
页数:12
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