A mild method for ring-opening aminolysis of lactones

被引：35

作者：

Liu, WM ^{[1
]}

Xu, DD ^{[1
]}

Repic, O ^{[1
]}

Blacklock, TJ ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 13期

关键词：

lactone; aminolysis; sodium; 2-ethylhexanoate;

D O I：

10.1016/S0040-4039(01)00196-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and general method for lactone aminolysis is reported. Sodium 2-ethylhexanoate (NaEH) is found to serve both as a base and a catalyst in aminolysis of a variety of lactones by benzylamine hydrochloride. The nearly neutral pH conditions make this method applicable to many acid/base sensitive substrates. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2439 / 2441

页数：3

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