A mild method for ring-opening aminolysis of lactones

被引:35
作者
Liu, WM [1 ]
Xu, DD [1 ]
Repic, O [1 ]
Blacklock, TJ [1 ]
机构
[1] Novartis Inst Biomed Res, E Hanover, NJ 07936 USA
关键词
lactone; aminolysis; sodium; 2-ethylhexanoate;
D O I
10.1016/S0040-4039(01)00196-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A mild and general method for lactone aminolysis is reported. Sodium 2-ethylhexanoate (NaEH) is found to serve both as a base and a catalyst in aminolysis of a variety of lactones by benzylamine hydrochloride. The nearly neutral pH conditions make this method applicable to many acid/base sensitive substrates. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2439 / 2441
页数:3
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