Serum hepatocyte growth factor concentration in patients with various degrees of chronic renal failure

被引：11

作者：

Chang, HG

Okuda, T

Nomura, Y

Nagao, T

Nakamura, T

Kurokawa, K

Katoh, T

机构：

[1] UNIV TOKYO,SCH MED,DEPT INTERNAL MED 4,TOKYO 112,JAPAN

[2] UNIV TOKYO,SCH MED,DEPT INTERNAL MED 1,TOKYO 112,JAPAN

[3] UNIV TOKYO,INST IND SCI,TOKYO,JAPAN

[4] TOKYO TEISHIN HOSP,TOKYO,JAPAN

[5] OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT BIOCHEM,OSAKA 553,JAPAN

来源：

NEPHROLOGY | 1996年 / 2卷 / 03期

关键词：

chronic renal failure; haemodialysis; hepatocyte growth factor;

D O I：

10.1111/j.1440-1797.1996.tb00084.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Serum hepatocyte growth factor (HGF) concentrations were measured in healthy volunteers, chronic renal failure patients without renal replacement therapy and haemodialysis patients. Serum HGF concentrations in healthy volunteers, chronic renal failure patients and haemodialysis patients were 0.18 +/- 0.04 (s.d.), 0.28 +/- 0.06 and 0.46 +/- 0.22 ng/mL, respectively. Serum HGF concentration in chronic renal failure patients was significantly higher than that in healthy volunteers. Serum HGF concentration in haemodialysis patients was significantly higher than those in healthy volunteers and chronic renal failure patients. There was no regression of serum HGF concentration on age, sex, history of haemodialysis, prehaemodialysis serum creatinine concentration, and serum tumour necrosis factor (TNF)-alpha concentration. We conclude that chronic renal disease and haemodialysis therapy are contributing factors to an increased serum HGF concentration.

引用

页码：175 / 179

页数：5

共 29 条

[11] EXPRESSIONS OF RECEPTOR GENE FOR HEPATOCYTE GROWTH-FACTOR IN KIDNEY AFTER UNILATERAL NEPHRECTOMY AND RENAL INJURY [J].