New neo-clerodane diterpenoids from Scutellaria barbata with cytotoxic activities

被引：51

作者：

Dai, Sheng-Jun ^{[1
]}

Qu, Gui-Wu ^{[2
]}

Yu, Qun-Ying ^{[1
]}

Zhang, De-Wu ^{[1
]}

Li, Gui-Sheng ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

[2] Ocean Univ China, Coll Food Sci & Technol, Qingdao 266003, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Scutellaria barbata D. Don; Labiatae; Neo-clerodane diterpenoid; Scutehenanine H; 6-(2,3-epoxy-2-isopropyl-n-propoxyl) barbatin C; Cytotoxic activity; ORIENTALIS SUBSP PINNATIFIDA; CANCER; CELLS; RESISTANT;

D O I：

10.1016/j.fitote.2010.01.001

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer lines, and gave IC(50) values in the range OF 2.0-4.2 mu M. (C) 2010 Elsevier B.V. All rights reserved.

引用

收藏

页码：737 / 741

页数：5

相关论文

共 17 条

[1]

Natural and hemisynthetic neoclerodane diterpenoids from Scutellaria and their antifeedant activity [J].

Bruno, M ;

Piozzi, F ;

Rosselli, S .

NATURAL PRODUCT REPORTS, 2002, 19 (03) :357-378

[2]

Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines [J].

Chang, CI ;

Kuo, CC ;

Chang, JY ;

Kuo, YH .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (01) :91-93

[3]

Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells [J].

Chang, JY ;

Chang, CY ;

Kuo, CC ;

Chen, LT ;

Wein, YS ;

Kuo, YH .

MOLECULAR PHARMACOLOGY, 2004, 65 (01) :77-84

[4]

Chang JY, 2002, CANCER RES, V62, P3716

[5]

Crdenas J., 1994, Fortschr. der Chemie Organischer Naturstoffe/Progress Chem. Organic Natural Prod, V63, P107, DOI DOI 10.1007/978-3-7091-9281-8

[6]

New neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities [J].

Dai, Sheng-Jun ;

Liang, Dong-Dong ;

Ren, Yan ;

Liu, Ke ;

Shen, Li .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (02) :207-209

[7]

Bioactive ent-clerodane diterpenoids from Scutellaria barbata [J].

Dai, Sheng-Jun ;

Sun, Jing-Yong ;

Ren, Yan ;

Liu, Ke ;

Shen, Li .

PLANTA MEDICA, 2007, 73 (11) :1217-1220

[8]

neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities [J].

Dai, Sheng-Jun ;

Tao, Jia-Yi ;

Liu, Ke ;

Jiang, Yong-Tao ;

Shen, Li .

PHYTOCHEMISTRY, 2006, 67 (13) :1326-1330

[9]

THE REARRANGEMENT OF ALPHA-BETA-UNSATURATED ALCOHOLS TO SATURATED ALDEHYDES AND KETONES .1. THE PREPARATION OF ALPHA-BETA-UNSATURATED ALCOHOLS AND 1-2-DIOLS AND THEIR PROTOTROPIC CHANGE [J].

GREEN, MB ;

HICKINBOTTOM, WJ .

JOURNAL OF THE CHEMICAL SOCIETY, 1957, (JUL) :3262-3270

[10]

Neo-clerodane diterpenoids from Scutellaria orientalis subsp pinnatifida [J].

Malakov, PY ;

Papanov, GY .

PHYTOCHEMISTRY, 1996, 43 (01) :173-178