Automated liquid-liquid extraction workstation for library synthesis and its use in the parallel and chromatography-free synthesis of 2-Alkyl-3-alkyl-4-(3H)-quinazolinones

被引：16

作者：

Carpintero, Mercedes ^{[1
]}

Cifuentes, Marta ^{[1
]}

Ferritto, Rafael ^{[1
]}

Haro, Ruben ^{[1
]}

Toledo, Miguel A. ^{[1
]}

机构：

[1] Ctr Invest Lilly, E-28108 Madrid, Spain

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2007年 / 9卷 / 05期

关键词：

D O I：

10.1021/cc070051t

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An automated liquid-liquid extraction workstation has been developed. This module processes up to 96 samples in an automated and parallel mode avoiding the time-consuming and intensive sample manipulation during the workup process. To validate the workstation, a highly automated and chromatography-free synthesis of differentially substituted quinazolin-4(3H)-ones with two diversity points has been carried out using isatoic anhydride as starting material.

引用

收藏

页码：818 / 822

页数：5

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