DNA Self-assembly for Nanomedicine

被引：116

作者：

Chhabra, Rahul

Sharma, Jaswinder

Liu, Yan

Rinker, Sherri

Yan, Hao ^{[1
]}

机构：

[1] Arizona State Univ, Biodesign Inst, Ctr Single Mol Biophys, Tempe, AZ 85287 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 06期

基金：

美国国家科学基金会;

关键词：

Self-assembly; DNA Nanotechnology; DNA tiles; DNA nanoarrays; Biosensing; IN-VITRO SELECTION; FINITE-SIZE; RNA LIGANDS; ARRAYS; NANOARRAYS; CONSTRUCTION; DESIGN; TILES; TEMPLATES; COMPLEXES;

D O I：

10.1016/j.addr.2010.03.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Self-assembling DNA nanostructures based on rationally designed DNA branch junction molecules has recently led to the construction of patterned supramolecular structures with increased complexities. An intrinsic value of DNA tiles and patterns lies in their utility as molecular pegboard for deterministic positioning of molecules or particles with accurate distance and architectural control. This review will discuss the state-of-art developments in self-assembled DNA nanostructural system. Biomedical aspects of information guided DNA nanostructures will also be summarized. We illustrate both the use of simple DNA artworks for sensing, computation, drug delivery and the application of more complex DNA architectures as scaffolds for the construction of protein and nanoparticle arrays. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：617 / 625

页数：9

共 72 条

[31] Self-assembled signaling aptamer DNA arrays for protein detection [J].