Studies on the genotoxicity of chromium: from the test tube to the cell

被引：227

作者：

Codd, R ^{[1
]}

Dillon, CT ^{[1
]}

Levina, A ^{[1
]}

Lay, PA ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Ctr Heavy Met Res, Sydney, NSW 2006, Australia

来源：

COORDINATION CHEMISTRY REVIEWS | 2001年 / 216卷

基金：

英国医学研究理事会; 澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

cell permeability; cellular genotoxicity; chromium; DNA-damage; hydroxy radical; intracellular spectroscopy; mechanisms of reduction; organic radicals;

D O I：

10.1016/S0010-8545(00)00408-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A critical review of the relevance of in vitro chemical studies to Cr-induced cancers is given. In particular, the nature of the most likely reductants. the species that stabilise intermediates and the mechanisms of DNA damage and damage to transcription proteins are discussed. It is concluded that the major damaging species responsible for the genotoxicity include Cr(V), Cr(IV) and/or reactive organic intermediates, These studies on the chemistry are also related to spectroscopic and other studies on mammalian cells. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：537 / 582

页数：46

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