Gene regulation - Expression and silencing coupled

被引:8
作者
Buratowski, S
Moazed, D
机构
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
关键词
D O I
10.1038/4351174b
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The RNA interference pathway can inhibit the expression of specific genes. It now seems that an essential component of the silencing process is the gene-expression machinery itself.
引用
收藏
页码:1174 / 1175
页数:2
相关论文
共 10 条
[1]   Epigenetic consequences of nucleosome dynamics [J].
Ahmad, K ;
Henikoff, S .
CELL, 2002, 111 (03) :281-284
[2]   The RITS complex - A direct link between small RNA and heterochromatin [J].
Ekwall, K .
MOLECULAR CELL, 2004, 13 (03) :304-305
[3]   Tails of intrigue: Phosphorylation of RNA polymerase II mediates histone methylation [J].
Hampsey, M ;
Reinberg, D .
CELL, 2003, 113 (04) :429-432
[4]   RNA polymerase II is required for RNAi-dependent heterochromatin assembly [J].
Kato, H ;
Goto, DB ;
Martienssen, RA ;
Urano, T ;
Furukawa, K ;
Murakami, Y .
SCIENCE, 2005, 309 (5733) :467-469
[5]  
Kim JK, 2005, SCIENCE, V308, P1164, DOI 10.1126/science.1109267
[6]   An extensive network of coupling among gene expression machines [J].
Maniatis, T ;
Reed, R .
NATURE, 2002, 416 (6880) :499-506
[7]   Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs [J].
Motamedi, MR ;
Verdel, A ;
Colmenares, SU ;
Gerber, SA ;
Gygi, SP ;
Moazed, D .
CELL, 2004, 119 (06) :789-802
[8]   RETRACTED: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription (Retracted article. See vol. 437, pg. 1057, 2005) [J].
Schramke, V ;
Sheedy, DM ;
Denli, AM ;
Bonila, C ;
Ekwall, K ;
Hannon, GJ ;
Allshire, RC .
NATURE, 2005, 435 (7046) :1275-1279
[9]   Mechanism of transcription through the nucleosome by eukaryotic RNA polymerase [J].
Studitsky, VM ;
Kassavetis, GA ;
Geiduschek, EP ;
Felsenfeld, G .
SCIENCE, 1997, 278 (5345) :1960-1963
[10]   Finding the right template: RNA pol IV, a plant-specific RNA polymerase [J].
Vaughn, MW ;
Martienssen, RA .
MOLECULAR CELL, 2005, 17 (06) :754-756