Solution and solid-supported synthesis of 3,4,5-trisubstituted 1,2,4-triazole-based peptidomimetics

被引：65

作者：

Boeglin, D

Cantel, S

Heitz, A

Martinez, J

Fehrentz, JA

机构：

[1] Univ Montpellier I, LAPP, Fac Pharm, CNRS,UMR 5810, F-34093 Montpellier 5, France

[2] Univ Montpellier 2, F-34093 Montpellier 5, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol035778e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3,4,5-Trisubstituted 1,2,4-triazoles were synthesized in solution from various thioamides and hydrazides in smooth experimental conditions leading to peptidomimetic scaffolds. This strategy was found to be compatible with the usual peptide synthesis protecting groups. This methodology was then applied on solid support by anchoring alpha-amino acids through their amino function to an activated carbonate resin.

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页码：4465 / 4468

页数：4

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