Pd-Catalyzed Intermolecular C-H Amination with Alkylamines

被引：386

作者：

Yoo, Eun Jeong ^{[1
]}

Ma, Sandy ^{[1
]}

Mei, Tian-Sheng ^{[1
]}

Chan, Kelvin S. L. ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 20期

关键词：

N BOND FORMATION; ELECTROPHILIC AMINATION; DIORGANOZINC REAGENTS; C(SP(3))-H BONDS; AMIDATION; SP(2); TEMPERATURE; ALKYLATION; INHIBITORS; CARBAZOLE;

D O I：

10.1021/ja202563w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-H amination of N-aryl benzamides with O-benzoyl hydroxylamines has been achieved with either Pd(II) or Pd(0) catalysts. Furthermore, we demonstrate that secondary amines can be directly used with benzoyl peroxide in a one-pot procedure that proceeds via the in situ generation of the appropriate O-benzoyl hydroxylamines. This catalytic reaction provides a new disconnection for the convergent synthesis of tertiary and secondary arylalkyl amines starting from benzoic acids.

引用

页码：7652 / 7655

页数：4

共 43 条

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