The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis

被引:203
作者
Dinoff, Adam [1 ,2 ]
Herrmann, Nathan [1 ,3 ]
Swardfager, Walter [1 ,2 ]
Liu, Celina S. [1 ,2 ]
Sherman, Chelsea [1 ]
Chan, Sarah [1 ]
Lanctot, Krista L. [1 ,2 ,3 ]
机构
[1] Sunnybrook Res Inst, Neuropsychopharmacol Res Grp, Hurvitz Brain Sci Program, Toronto, ON, Canada
[2] Univ Toronto, Dept Pharmacol & Toxicol, Fac Med, Toronto, ON, Canada
[3] Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada
来源
PLOS ONE | 2016年 / 11卷 / 09期
基金
加拿大健康研究院;
关键词
METABOLIC RISK-FACTORS; AEROBIC EXERCISE; RESISTANCE EXERCISE; PHYSICAL-ACTIVITY; GROWTH-FACTOR; PLASMA BDNF; COGNITIVE IMPAIRMENT; HIPPOCAMPAL FUNCTION; CIRCULATING LEVELS; BIPOLAR DISORDER;
D O I
10.1371/journal.pone.0163037
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background The mechanisms through which physical activity supports healthy brain function remain to be elucidated. One hypothesis suggests that increased brain-derived neurotrophic factor (BDNF) mediates some cognitive and mood benefits. This meta-analysis sought to determine the effect of exercise training on resting concentrations of BDNF in peripheral blood. Methods MEDLINE, Embase, PsycINFO, SPORTDiscus, Rehabilitation & Sports Medicine Source, and CINAHL databases were searched for original, peer-reviewed reports of peripheral blood BDNF concentrations before and after exercise interventions >= 2 weeks. Risk of bias was assessed using standardized criteria. Standardized mean differences (SMDs) were generated from random effects models. Risk of publication bias was assessed using funnel plots and Egger's test. Potential sources of heterogeneity were explored in subgroup analyses. Results In 29 studies that met inclusion criteria, resting concentrations of peripheral blood BDNF were higher after intervention (SMD = 0.39, 95% CI: 0.17-0.60, p<0.001). Subgroup analyses suggested a significant effect in aerobic (SMD = 0.66, 95% CI: 0.33-0.99, p<0.001) but not resistance training (SMD = 0.07, 95% CI: -0.15 - 0.30, p = 0.52) interventions. No significant difference in effect was observed between males and females, nor in serum vs plasma. Conclusion Aerobic but not resistance training interventions increased resting BDNF concentrations in peripheral blood.
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页数:21
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