Failure to Detect Xenotropic Murine Leukemia Virus-Related Virus in Blood of Individuals at High Risk of Blood-Borne Viral Infections

被引：39

作者：

Barnes, Eleanor ^{[1
,2
]}

Flanagan, Peter ^{[1
,2
]}

Brown, Anthony ^{[1
,2
]}

Robinson, Nicola ^{[1
,2
]}

Brown, Helen ^{[1
,2
]}

McClure, Myra ^{[5
]}

Oxenius, Annette ^{[6
]}

Collier, Jane ^{[4
]}

Weber, Jonathan ^{[5
]}

Guenthard, Huldrych F. ^{[7
,8
]}

Hirschel, Bernard ^{[9
]}

Fidler, Sarah ^{[5
]}

Phillips, Rodney ^{[1
,2
,3
]}

Frater, John ^{[1
,2
,3
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Oxford OX1 3SY, England

[2] Oxford NIHR Biomed Res Ctr, Oxford, England

[3] James Martin 21st Century Sch, Oxford, England

[4] John Radcliffe Hosp NHS Trust, Dept Gastroenterol, Oxford, England

[5] Univ London Imperial Coll Sci Technol & Med, Div Med, Wright Fleming Inst, St Marys Hosp, London, England

[6] Univ Zurich, ETH Zurich, Inst Microbiol, Zurich, Switzerland

[7] Univ Zurich, Div Infect Dis, Zurich, Switzerland

[8] Univ Zurich, Hosp Epidemiol, Zurich, Switzerland

[9] Univ Hosp, Div Infect Dis, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 10期

基金：

英国惠康基金; 瑞士国家科学基金会;

关键词：

CHRONIC-FATIGUE-SYNDROME; PROSTATE-CANCER PATIENTS; HIV-INFECTION; XMRV; PREVALENCE; RETROVIRUS; ABSENCE; COHORT; CELLS;

D O I：

10.1086/657167

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.

引用

页码：1482 / 1485

页数：4

共 15 条

[1] No evidence of XMRV in irish prostate cancer patients with the R462q mutation [J].

D'Arcy, F. ;

Foley, R. ;

Perry, A. ;

Marignol, L. ;

Lawler, M. ;

Gaffney, E. ;

Watson, R. G. W. ;

Fitzpatrick, J. M. ;

Lynch, T. H. .

EUROPEAN UROLOGY SUPPLEMENTS, 2008, 7 (03) :271-271

[2] Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome [J].

Erlwein, Otto ;

Kaye, Steve ;

McClure, Myra O. ;

Weber, Jonathan ;

Wills, Gillian ;

Collier, David ;

Wessely, Simon ;

Cleare, Anthony .

PLOS ONE, 2010, 5 (01)

[3] Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort [J].

Fidler, Sarah ;

Fox, Julie ;

Touloumi, Giota ;

Pantazis, Nikos ;

Porter, Kholoud ;

Babiker, Abdel ;

Weber, Jonathan .

AIDS, 2007, 21 (10) :1283-1291

[4] Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer [J].

Fischera, Nicole ;

Hellwinkel, Olaf ;

Schulz, Claudia ;

Chun, Felix K. H. ;

Huland, Hartwig ;

Aepfelbacher, Martin ;

Schlomm, Thorsten .

JOURNAL OF CLINICAL VIROLOGY, 2008, 43 (03) :277-283

[5] Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome [J].

Groom, Harriet C. T. ;

Boucherit, Virginie C. ;

Makinson, Kerry ;

Randal, Edward ;

Baptista, Sarah ;

Hagan, Suzanne ;

Gow, John W. ;

Mattes, Frank M. ;

Breuer, Judith ;

Kerr, Jonathan R. ;

Stoye, Jonathan P. ;

Bishop, Kate N. .

RETROVIROLOGY, 2010, 7

[6] Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients [J].

Hohn, Oliver ;

Krause, Hans ;

Barbarotto, Pia ;

Niederstadt, Lars ;

Beimforde, Nadine ;

Denner, Joachim ;

Miller, Kurt ;

Kurth, Reinhard ;

Bannert, Norbert .

RETROVIROLOGY, 2009, 6 :92

[7] CD8+ T-cell responses to different HIV proteins have discordant associations with viral load [J].

Kiepiela, Photini ;

Ngumbela, Kholiswa ;

Thobakgale, Christina ;

Ramduth, Dhanwanthie ;

Honeyborne, Isobella ;

Moodley, Eshia ;

Reddy, Shabashini ;

de Pierres, Chantal ;

Mncube, Zenele ;

Mkhwanazi, Nompumelelo ;

Bishop, Karen ;

van der Stok, Mary ;

Nair, Kriebashnie ;

Khan, Nasreen ;

Crawford, Hayley ;

Payne, Rebecca ;

Leslie, Alasdair ;

Prado, Julia ;

Prendergast, Andrew ;

Frater, John ;

McCarthy, Noel ;

Brander, Christian ;

Learn, Gerald H. ;

Nickle, David ;

Rousseau, Christine ;

Coovadia, Hoosen ;

Mullins, James I. ;

Heckerman, David ;

Walker, Bruce D. ;

Goulder, Philip .

NATURE MEDICINE, 2007, 13 (01) :46-53

[8] Occurrence of leukaemia following gene therapy of X-linked SCID [J].

Kohn, DB ;

Sadelain, M ;

Glorioso, JC .

NATURE REVIEWS CANCER, 2003, 3 (07) :477-488

[9] RETRACTED: Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome (Retracted article. See vol. 334, pg. 1636, 2011) [J].

Lombardi, Vincent C. ;

Ruscetti, Francis W. ;

Das Gupta, Jaydip ;

Pfost, Max A. ;

Hagen, Kathryn S. ;

Peterson, Daniel L. ;

Ruscetti, Sandra K. ;

Bagni, Rachel K. ;

Petrow-Sadowski, Cari ;

Gold, Bert ;

Dean, Michael ;

Silverman, Robert H. ;

Mikovits, Judy A. .

SCIENCE, 2009, 326 (5952) :585-589

[10] Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection [J].

Oxenius, A ;

Price, DA ;

Günthard, HF ;

Dawson, SJ ;

Fagard, C ;

Perrin, L ;

Fischer, M ;

Weber, R ;

Plana, M ;

García, F ;

Hirschel, B ;

McLean, A ;

Phillips, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13747-13752

← 1 2 →