Copper-Catalyzed Synthesis of Quinazoline Derivatives via Ullmann-Type Coupling and Aerobic Oxidation

被引：135

作者：

Wang, Chen ^{[1
]}

Li, Shangfu ^{[2
]}

Liu, Hongxia ^{[2
]}

Jiang, Yuyang ^{[2
]}

Fu, Hua ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Key Lab Chem Biol Guangdong Prov, Grad Sch Shenzhen, Shenzhen 518057, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 22期

基金：

中国国家自然科学基金;

关键词：

C-O; EFFICIENT SYNTHESIS; ARYL HALIDES; ORTHO-SUBSTITUENT; CASCADE SYNTHESIS; N-ARYLATION; INHIBITORS; RECEPTOR; LIGAND; AMIDES;

D O I：

10.1021/jo101685d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient copper-catalyzed approach to quinazoline derivatives has been developed, and the protocol uses readily available substituted (2-bromophenyl)methylamines and amides as the starting materials, and the cascade reactions were performed under air via sequential Ullmann-type coupling and aerobic oxidation without addition of any ligand or additive The present method provides a convenient and practical strategy for synthesis of quinazoline derivatives

引用

页码：7936 / 7938

页数：3

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