Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

被引:61
作者
Grossmann, Vera [1 ]
Kern, Wolfgang [1 ]
Harbich, Stefan [1 ]
Alpermann, Tamara [1 ]
Jeromin, Sabine [1 ]
Schnittger, Susanne [1 ]
Haferlach, Claudia [1 ]
Haferlach, Torsten [1 ]
Kohlmann, Alexander [1 ]
机构
[1] MLL Munich Leukemia Lab, D-81377 Munich, Germany
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2011年 / 96卷 / 12期
关键词
T-cell ALL; prognosis; RUNX1; mutations; ACUTE MYELOID-LEUKEMIA; GENE; CLASSIFICATION; MALIGNANCIES; ADULT;
D O I
10.3324/haematol.2011.043919
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases. In this study, the mutational status of RUNX1 was investigated in 128 acute lymphoblastic leukemia patients. We detected a mutation rate of 18.3% (13 of 71) in patients with T-cell acute lymphoblastic leukemia, 3.8% (2 of 52) in patients with B-cell acute lymphoblastic leukemia and no mutation (0 of 5) in patients with natural killer cell leukemia, respectively. In T-cell acute lymphoblastic leukemia patients, RUNX1 mutations were significantly associated with higher age (P=0.017) and lower white blood cell count (P=0.038). Moreover, an inferior outcome was observed in the subgroup of early T-cell acute lymphoblastic leukemia patients carrying RUNX1 mutations for overall survival (P=0.043). In conclusion, RUNX1 mutations are an important novel biomarker for a comprehensive characterization of T-cell acute lymphoblastic leukemia with poor prognostic impact and have implications for use also in monitoring disease.
引用
收藏
页码:1874 / 1877
页数:4
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